THE S100A4 TRANSCRIPTIONAL INHIBITOR NICLOSAMIDE REDUCES PRO-INFLAMMATORY AND MIGRATORY PHENOTYPES OF MICROGLIA: IMPLICATIONS FOR AMYOTROPHIC LATERAL SCLEROSIS

S100A4, belonging to a large multifunctional S100 protein family, is a Ca2+-binding protein with a significant role in stimulating the motility of cancer and immune cells, as well as in promoting pro-inflammatory properties in different cell types.In the CNS, there is limited information concerning S100A4 presence and function.In this study, we ana

Improving the understanding of the complex relationship between genetic predispositions, environmental influences, and sociocultural factors in the development and progression of mental illness is crucial for Wooden Dollhouse optimizing treatment efficacy and addressing longstanding health disparities.This paper discusses the ethical, legal, and so

Egress (or Evacuation) Rug modelling has the purpose to simulate how the people inside a building can move outside in a safe manner and as quick as possible in case of an emergency.The goal can be to assess the safety of an existing building or a building design, to establish evacuation routes and install signage, or even to give real-time guidance

While personal blunt wraps relative deprivation (PRD) is recognized as a potential risk factor for aggression, the mechanisms underlying this relationship are not well understood.This study investigates how revenge motivation mediates the link between PRD and online aggression, as well as how a violent attitude moderates this connection.A total of

Alkaline lacustrine deposits are known for their high primary productivity, unique aquatic environments, and sedimentary patterns, which are conducive to the formation and preservation of organic matter.Consequently, related source rocks have significant hydrocarbon generation potential.The study of hydrocarbon source rocks in the Fengcheng Formati